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The Morning Dose #48: Youthful Skin, Deadly Test Levels, and Erectile Dysfunction

The ONLY Underground Biohacking Newsletter

Welcome to The Morning Dose, your one-stop shop for all things peptides, TRT, fitness, anti-aging, and everything in between.

Pour your morning coffee and lock in for this week’s groundbreaking news and rearch from the world of science-based biohacking, TRT, peptides and anti-aging.

In this week’s edition of The Morning Dose:

👶 Unlocking the Secret of Youthful Skin

💉 Is Low Testosterone Killing You?

🧭 Navigating the Complex World of 5-ARIs

🍆 The Truth About Testosterone and Erectile Dysfunction

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☕️ First time reading? I’m James, and this is The Morning Dose. Every week, our team scours hundreds of sources to bring you need-to-know news and insights you won’t find elsewhere. All in 5 minutes.

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🙋‍♂️ Featured Article

👶 Unlocking the Secret of Youthful Skin

Are you fed up with stubborn dark spots, uneven skin tone, and those pesky signs of aging?

You're definitely not alone!

Many people are battling these common skin issues, but we have some exciting news that could change your skincare game.

Introducing Decapeptide 12, a revolutionary peptide that's gaining massive recognition for its ability to tackle these concerns head-on.

Imagine smoother, more radiant skin that not only looks youthful but feels incredible too.

We’re here to unravel the science behind this powerhouse peptide and show you how it can transform your skin.

Suitable for all skin types, including sensitive skin, Decapeptide 12 offers a gentle yet powerful formulation that minimizes the risk of irritation.

Clinical studies have demonstrated significant improvement in skin tone and texture with regular use, highlighting its efficacy in promoting a radiant complexion.

It also stimulates collagen production, helping to reduce the appearance of wrinkles and fine lines, making your skin look youthful and vibrant.

Are you ready to take control of your skincare routine and unlock the secrets to healthier, more youthful-looking skin?

Dive into our comprehensive guide on Decapeptide 12 and discover how you can achieve a smoother, brighter complexion.

Click here to read the full article and embark on your journey to transformative skincare!

💉 Is Low Testosterone Killing You?

An analysis of data from 11 studies, involving over 24,100 participants, has revealed that men with endogenous testosterone levels below 213 ng/dL have a higher risk of dying from any cause.

This is a wake-up call for anyone supplementing or biohacking their hormone levels.

Testosterone levels naturally vary with age, but the American Urological Association defines low testosterone as less than 300 ng/dL.

Alarmingly, those with very low levels—less than 153 ng/dL—are at an even higher risk of dying from cardiovascular disease specifically!

It doesn't stop there; high luteinizing hormone levels, which indicate primary hypogonadism, and low estradiol concentrations also elevate mortality risk.

Interestingly, participants with lower concentrations of sex hormone-binding globulin (SHBG)—a protein that influences testosterone delivery to tissues—had about a 15% lower risk of dying from any cause and a 19% lower chance of dying specifically from cardiovascular disease.

This highlights the intricate balance needed in managing sex hormones for optimal health and longevity.

🧭 Navigating the Complex World of 5-ARIs

5α-reductase inhibitors (5-ARIs), specifically finasteride and dutasteride, are FDA-approved for tackling benign prostatic hyperplasia (BPH) and androgenic alopecia (male pattern hair loss).

These powerful medications work by blocking the enzyme 5α-reductase, slashing the conversion of testosterone into dihydrotestosterone (DHT), the hormone notorious for causing prostate enlargement and hair loss.

Imagine significantly reducing your prostate size and conquering those annoying urinary symptoms.

That's exactly what 5-ARIs do—finasteride can cut prostatic DHT by over 90%, shrinking the prostate and easing symptoms like nocturia and urgency.

Dutasteride takes it a step further, slashing DHT by up to 99% and chopping down prostate volume by 25%.

These reductions lead to a dramatic decrease in PSA levels, a crucial marker for prostate health.

However, with great power comes great responsibility.

While these drugs are powerful allies, they also come with potential side effects like erectile dysfunction, reduced libido, and gynecomastia.

It's essential to keep a close eye on your hormone levels and work with healthcare professionals to maintain a perfect balance.

Monitoring your PSA levels is crucial, as 5-ARIs can affect prostate cancer screenings.

For those of you supplementing with testosterone, balancing DHT and other hormones is critical.

Remember, the goal is to amplify your performance and well-being without compromising your health.

🍆 The Truth About Testosterone and Erectile Dysfunction

There’s some intriguing findings from a recent study underscoring the critical need for balanced hormonesespecially when supplementing with testosterone.

The study involved 398 men without hypoandrogenism (low testosterone levels) and aimed to uncover the relationship between various sex hormones and erectile dysfunction.

While testosterone is vital, the study found that it wasn't significantly associated with ED in men with normal levels.

Lower levels of dehydroepiandrosterone sulfate (DHEA-S) and higher levels of estradiol were significantly linked to ED.

This means that simply boosting testosterone might not be enough; you need to keep an eye on these other hormones too.

If you're supplementing with testosterone, be mindful of how it affects your overall hormone balance.

Regularly check your DHEA-S and estradiol levels.

Balance is key to optimizing performance and maintaining overall well-being.

Regular blood tests and consultations with healthcare professionals can help you fine-tune your regimen for the best results.

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-The Morning Dose

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Disclaimer: This content is NOT medical advice. The information included in these emails is intended for entertainment and informational purposes only.